ChloroquineV1, Main, Exploration, bibRecord, 002D17

Troleandomycin in the treatment of difficult asthma

Identifieur interne : 002D17 ( Main/Exploration ); précédent : 002D16; suivant : 002D18

Troleandomycin in the treatment of difficult asthma

Auteurs : Andrea Siracusa [Italie] ; Giuliana Brugnami [Italie] ; Tiziana Fiordi [Italie] ; Stefano Areni [Italie] ; Carla Severini [Italie] ; Alessandra Marabini [Italie]

Source :

The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 1993.

RBID : ISTEX:FF8FFA08EA6A1754F10282ABA1F80793726FF276

English descriptors

Teeft :
- Adverse effects, Airway obstruction, Allergy, Allergy clin immunol, Allergy clin immunol november, Allergy clin immunol volume, Alternate mornings, Asthma, Asthma patients, Asthmatic, Asthmatic attack, Asthmatic attacks, Beneficial effect, Bone mineral content, Bronchial asthma, Bronchial responsiveness, Clin, Corticosteroid, Cumulative dose, Cushingoid features, Difficult asthma, Diurnal variation, Expiratory, Expiratory volume, Gold salt, Gold salts, Greater increase, Immunol, Lung function, Methylprednisolone elimination, Nonresponders, Occupational medicine, Peak expiratory flow rate, Pefr, Persistent increase, Respiratory symptoms, Responder, Serum alanine aminotransferase, Severe asthma, Side effects, Systemic corticosteroids, Theophylline, Theophylline dose, Troleandomycin.

Abstract

Abstract: Background: For difficult asthma, treatment is aimed at improving airway obstruction and minimizing adverse effects of systemic corticosteroids. The combination of troleandomycin (TAO) with methylprednisolone (MP) reportedly has a beneficial steroid-sparing effect on difficult asthma. Methods: To test the steroid-sparing effect of TAO, 14 subjects with severe corticosteroid-dependent asthma were studied before and during treatment with MP and TAO. Results: Treatment with MP and TAO resulted in a clear reduction in respiratory symptoms, asthmatic attacks, corticosteroid and hospitalization requirements, improvement in pulmonary function tests, and a remarkable decrease in peak expiratory flow rate circadian variability when compared with the period before TAO treatment (with corticosteroids). Treatment with MP and TAO was fairly well tolerated. Only a reduction (−5.2%, p < 0.01) in bone mineral content and an increase in plasma glucose levels (from 81.7 to 94.3 mg/dl, p < 0.05) were found, in comparison with pre-TAO values. One subject discontinued MP-TAO treatment because of a mild but persistent increase in serum alanine aminotransferase. In an evaluation of the clinical and pulmonary function test results, eight of the 14 subjects were responders and six were nonresponders. During follow-up three subjects discontinued TAO and consequently had an asthmatic attack after 4, 7, or 15 days, respectively. Conclusions: This study confirms that treatment with MP and TAO has a beneficial effect in a subgroup of severely steroid-dependent asthma patients.

Url:

https://api.istex.fr/ark:/67375/6H6-D4K5PGDL-F/fulltext.pdf

DOI: 10.1016/0091-6749(93)90010-D

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000781
to stream Istex, to step Curation: 000781
to stream Istex, to step Checkpoint: 001A97
to stream Main, to step Merge: 002D82
to stream Main, to step Curation: 002D17

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Troleandomycin in the treatment of difficult asthma</title>
<author><name sortKey="Siracusa, Andrea" sort="Siracusa, Andrea" uniqKey="Siracusa A" first="Andrea" last="Siracusa">Andrea Siracusa</name>
</author>
<author><name sortKey="Brugnami, Giuliana" sort="Brugnami, Giuliana" uniqKey="Brugnami G" first="Giuliana" last="Brugnami">Giuliana Brugnami</name>
</author>
<author><name sortKey="Fiordi, Tiziana" sort="Fiordi, Tiziana" uniqKey="Fiordi T" first="Tiziana" last="Fiordi">Tiziana Fiordi</name>
</author>
<author><name sortKey="Areni, Stefano" sort="Areni, Stefano" uniqKey="Areni S" first="Stefano" last="Areni">Stefano Areni</name>
</author>
<author><name sortKey="Severini, Carla" sort="Severini, Carla" uniqKey="Severini C" first="Carla" last="Severini">Carla Severini</name>
</author>
<author><name sortKey="Marabini, Alessandra" sort="Marabini, Alessandra" uniqKey="Marabini A" first="Alessandra" last="Marabini">Alessandra Marabini</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:FF8FFA08EA6A1754F10282ABA1F80793726FF276</idno>
<date when="1993" year="1993">1993</date>
<idno type="doi">10.1016/0091-6749(93)90010-D</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-D4K5PGDL-F/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000781</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000781</idno>
<idno type="wicri:Area/Istex/Curation">000781</idno>
<idno type="wicri:Area/Istex/Checkpoint">001A97</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001A97</idno>
<idno type="wicri:doubleKey">0091-6749:1993:Siracusa A:troleandomycin:in:the</idno>
<idno type="wicri:Area/Main/Merge">002D82</idno>
<idno type="wicri:Area/Main/Curation">002D17</idno>
<idno type="wicri:Area/Main/Exploration">002D17</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Troleandomycin in the treatment of difficult asthma</title>
<author><name sortKey="Siracusa, Andrea" sort="Siracusa, Andrea" uniqKey="Siracusa A" first="Andrea" last="Siracusa">Andrea Siracusa</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>From the Institute of Occupational Medicine, University of Perugia Perugia</wicri:regionArea>
<wicri:noRegion>University of Perugia Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brugnami, Giuliana" sort="Brugnami, Giuliana" uniqKey="Brugnami G" first="Giuliana" last="Brugnami">Giuliana Brugnami</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>From the Institute of Occupational Medicine, University of Perugia Perugia</wicri:regionArea>
<wicri:noRegion>University of Perugia Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fiordi, Tiziana" sort="Fiordi, Tiziana" uniqKey="Fiordi T" first="Tiziana" last="Fiordi">Tiziana Fiordi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>From the Institute of Occupational Medicine, University of Perugia Perugia</wicri:regionArea>
<wicri:noRegion>University of Perugia Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Areni, Stefano" sort="Areni, Stefano" uniqKey="Areni S" first="Stefano" last="Areni">Stefano Areni</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>From the Institute of Occupational Medicine, University of Perugia Perugia</wicri:regionArea>
<wicri:noRegion>University of Perugia Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Severini, Carla" sort="Severini, Carla" uniqKey="Severini C" first="Carla" last="Severini">Carla Severini</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>From the Institute of Occupational Medicine, University of Perugia Perugia</wicri:regionArea>
<wicri:noRegion>University of Perugia Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marabini, Alessandra" sort="Marabini, Alessandra" uniqKey="Marabini A" first="Alessandra" last="Marabini">Alessandra Marabini</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>From the Institute of Occupational Medicine, University of Perugia Perugia</wicri:regionArea>
<wicri:noRegion>University of Perugia Perugia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">The Journal of Allergy and Clinical Immunology</title>
<title level="j" type="abbrev">YMAI</title>
<idno type="ISSN">0091-6749</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1993">1993</date>
<biblScope unit="volume">92</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="677">677</biblScope>
<biblScope unit="page" to="682">682</biblScope>
</imprint>
<idno type="ISSN">0091-6749</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0091-6749</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adverse effects</term>
<term>Airway obstruction</term>
<term>Allergy</term>
<term>Allergy clin immunol</term>
<term>Allergy clin immunol november</term>
<term>Allergy clin immunol volume</term>
<term>Alternate mornings</term>
<term>Asthma</term>
<term>Asthma patients</term>
<term>Asthmatic</term>
<term>Asthmatic attack</term>
<term>Asthmatic attacks</term>
<term>Beneficial effect</term>
<term>Bone mineral content</term>
<term>Bronchial asthma</term>
<term>Bronchial responsiveness</term>
<term>Clin</term>
<term>Corticosteroid</term>
<term>Cumulative dose</term>
<term>Cushingoid features</term>
<term>Difficult asthma</term>
<term>Diurnal variation</term>
<term>Expiratory</term>
<term>Expiratory volume</term>
<term>Gold salt</term>
<term>Gold salts</term>
<term>Greater increase</term>
<term>Immunol</term>
<term>Lung function</term>
<term>Methylprednisolone elimination</term>
<term>Nonresponders</term>
<term>Occupational medicine</term>
<term>Peak expiratory flow rate</term>
<term>Pefr</term>
<term>Persistent increase</term>
<term>Respiratory symptoms</term>
<term>Responder</term>
<term>Serum alanine aminotransferase</term>
<term>Severe asthma</term>
<term>Side effects</term>
<term>Systemic corticosteroids</term>
<term>Theophylline</term>
<term>Theophylline dose</term>
<term>Troleandomycin</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Background: For difficult asthma, treatment is aimed at improving airway obstruction and minimizing adverse effects of systemic corticosteroids. The combination of troleandomycin (TAO) with methylprednisolone (MP) reportedly has a beneficial steroid-sparing effect on difficult asthma. Methods: To test the steroid-sparing effect of TAO, 14 subjects with severe corticosteroid-dependent asthma were studied before and during treatment with MP and TAO. Results: Treatment with MP and TAO resulted in a clear reduction in respiratory symptoms, asthmatic attacks, corticosteroid and hospitalization requirements, improvement in pulmonary function tests, and a remarkable decrease in peak expiratory flow rate circadian variability when compared with the period before TAO treatment (with corticosteroids). Treatment with MP and TAO was fairly well tolerated. Only a reduction (−5.2%, p < 0.01) in bone mineral content and an increase in plasma glucose levels (from 81.7 to 94.3 mg/dl, p < 0.05) were found, in comparison with pre-TAO values. One subject discontinued MP-TAO treatment because of a mild but persistent increase in serum alanine aminotransferase. In an evaluation of the clinical and pulmonary function test results, eight of the 14 subjects were responders and six were nonresponders. During follow-up three subjects discontinued TAO and consequently had an asthmatic attack after 4, 7, or 15 days, respectively. Conclusions: This study confirms that treatment with MP and TAO has a beneficial effect in a subgroup of severely steroid-dependent asthma patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Siracusa, Andrea" sort="Siracusa, Andrea" uniqKey="Siracusa A" first="Andrea" last="Siracusa">Andrea Siracusa</name>
</noRegion>
<name sortKey="Areni, Stefano" sort="Areni, Stefano" uniqKey="Areni S" first="Stefano" last="Areni">Stefano Areni</name>
<name sortKey="Brugnami, Giuliana" sort="Brugnami, Giuliana" uniqKey="Brugnami G" first="Giuliana" last="Brugnami">Giuliana Brugnami</name>
<name sortKey="Fiordi, Tiziana" sort="Fiordi, Tiziana" uniqKey="Fiordi T" first="Tiziana" last="Fiordi">Tiziana Fiordi</name>
<name sortKey="Marabini, Alessandra" sort="Marabini, Alessandra" uniqKey="Marabini A" first="Alessandra" last="Marabini">Alessandra Marabini</name>
<name sortKey="Severini, Carla" sort="Severini, Carla" uniqKey="Severini C" first="Carla" last="Severini">Carla Severini</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D17 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D17 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:FF8FFA08EA6A1754F10282ABA1F80793726FF276
   |texte=   Troleandomycin in the treatment of difficult asthma
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Troleandomycin in the treatment of difficult asthma

Troleandomycin in the treatment of difficult asthma

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri